Electrospinning of food grade nanofibers from cellulose acetate-egg albumen blend for bioactive compound delivery = การผลิตเส้นใยนาโนผสมของเซลลูโลสอะซิเตทกับไข่ขาวเพื่อให้เป็นตัวพาสารออกฤทธิ์ทางชีวภาพ


จักรกฤษณ์ เคร่งวิทยา


วิทยานิพนธ์. (2008) 50 หน้า



Due to the reported potential of nanofibers for frug delivery, egg albumen (EA)-cellulose acetate (CA) blend nanofibers for delivery of gastrointestinal (GI) tract treatment drug were successfully fabricated in previous work (Patapeejumruswong, 2007). EA is considered as a gook pH-controlled release natural biopolymer whilst CA provides a good gastric protection property. In this study, the release chracteristics of CA-EA blend electrospun film carrying vitamin B2 (Vit. B2), a water soluble bioactive compound, were investigated. The film was electrospun from a blend solution of CA in 85% acetic acid (20% w/w) and EA in neat formic acid (12% w/w) A non-inonic sufactant, namely, Tween 40 was added to promote fiber formation. The solid blending ratio of CA:EA:Tween:vit. B2 was 91:5:3:1. A study of the release property of CA-EA electrospun fibrous film was performed in buffer solutions of pH 1.2 and pH 7.4 at 37±0.5 °C for 9 h. Mass release was measured by periodically sampling the release medium to measure its optical density by spectrophotometry. The mechanism and constant rate of rrate of release were obtained by fitting the cumulative mass release to a simple power law model. Overall, the results showed that the release rates in acidic and alkaline buffers were not significantly different. The release was driven by diffusion through the swollen matrix and the release rate depended on the solubility of the encapsulated compound and of the release medium. This study showed a potential in using the CA-EA blend fibrous film for delivery of bioactive compound in GI tract. The release rate could be regulated by altering either the swelling property of the blend polymer or the solubility of the encapsulated compound in the target GI tract solution