Expression of lipid transporters–ABCA1, ABCB11, and ABCG1, in intrahepatic cholangiocarcinoma

  • Sasiwan Laohasinnarong

  • Noppadol Larbcharoensub


Department of Pathology, Faculty of Medicine at Ramathibodi Hospital, Mahidol University






01 มกราคม 2541


Intrahepatic cholangiocarcinoma (ICC) is a primary adenocarcinoma arising from intrahepatic bile duct epithelium. The incidence of ICC accounts for 90% among all hepatic cancers in the north east of Thailand. Major complications include cholestasis associated with accumulation of bilirubin and bile acids in blood. The ATP binding cassette transporters ABCA1, ABCB11 and ABCG1 are involved in the transport of cholesterol and bile acids in hepatocytes. However, their functional role(s) in cholangiocytes have not been determined. In this study, we examined the expression profiles of ABCA1, ABCB11, and ABCG1 in normal cholangiocytes and ICC tissues from 20 patients. We found that normal cholangiocytes expressed ABCA1 and ABCB11, but not and ABCG1. All of ICC tissues (100%) expressed ABCA1 whereas ABCB11 was found in 9 patients (45%) in cholangiocytes, but not in bile canaliculi. Surprisingly, 2 cases revealed nuclear expression of ABCG1 in cholangiocytes, 6 cases with cytoplasmic expression and one with both. These results shed light on possible involvement of these lipid transporters in ICC development.